Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 207/16 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 201/02 (2006.01) C07D 207/09 (2006.01) C07D 207/12 (2006.01) C07D 207/22 (2006.01) C07D 207/48 (2006.01) C07D 261/02 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 411/00 (2006.01) C07D 413/00 (2006.01) C07D 413/12 (2006.01) C07D 417/00 (2006.01) C07D 453/

Patent

CA 2262117

The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula (I), or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(=NH)NH2 and the other H and J1 and J2 may be O or CH2, which are useful as inhibitors of factor Xa.

Cette invention a trait à des amidinophényl-pyrrolidines, -pyrrolines et -isoxazolidines ainsi qu'à leurs dérivés ou à leurs sels, acceptables du point de vue pharmaceutique, ces substances étant représentées par la formule (I) dans laquelle soit D, soit D' peuvent représenter C(=NH)NH¿2? tandis que H et J?1¿ et J?3¿ peuvent représenter O ou CH¿2?. Ces substances sont utilisées comme inhibiteurs du facteur Xa.

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