C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) C07K 14/47 (2006.01) C12N 15/67 (2006.01) C12Q 1/66 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2204871
The application concerns methods for modulating transcription from the amyloid .beta.-protein precursor (APP) promoter. The upstreaam stimulatory factor (USF) is described as being capable of activating transcription from the APP promoter. Also described are USF binding compounds which are capable of down- regulating expression from the APP promoter. Preferred USF binding compounds are the amyloid precursor-like proteins APLP1 and APLP2. The application further concerns a screening assay for determining which candidate USF binding compounds are capable of causing down-regulation of transcription from the APP promoter.
L'inventin concerne des procédés de modulation de transcription à partir du promoteur de la protéine précurseur amyloïde-.beta. (APP). Le facteur de stimulation en amont (USF) y est décrit comme étant capable d'activer une transcription à partir du promoteur APP. Des composés de liaison USF, également décrits, sont capables d'effectuer la rétro-régulation de l'expression du promoteur APP. Les composés de liaison USF préférés sont les protéines de type précurseur amyloïde APLP1 et APLP2. La demande concerne, de surcroît, une méthode de criblage permettant de décider quels composés de liaison USF candidats sont capables de provoquer la rétro-régulation de la transcription à partir du promoteur APP.
Kovacs Dora M.
Tanzi Rudolph E.
Mbm & Co.
The General Hospital Corporation
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