A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/28 (2006.01) A61K 31/403 (2006.01)
Patent
CA 2734095
The present invention relates to a pharmaceutical composition for controlled delivery of at least one active ingredient into an aqueous phase, said pharmaceutical composition comprising: a tablet, preferably obtainable by compression, said tablet comprising said at least one active ingredient and optionally excipients; and a coating, applied on said tablet, said coating covering at least part of said tablet to impede the release of said at least one active ingredient from at least part of the surface of said tablet, said coating being applied in a manner allowing the release of said at least one active ingredient from said tablet after contacting said pharmaceutical composition with said aqueous phase, establishing one or more degradation surfaces of said tablet; wherein the first derivative of the area of each degradation surface with respect to time is larger than or equal to zero.
La présente invention concerne une composition pharmaceutique destinée à la délivrance contrôlée dau moins un principe actif dans une phase aqueuse, ladite composition pharmaceutique comprenant : un comprimé, pouvant de préférence être obtenu par compression, ledit comprimé comprenant ledit ou lesdits principes actifs et facultativement des excipients; et un enrobage, appliqué sur ledit comprimé, ledit enrobage couvrant au moins une partie dudit comprimé pour empêcher la libération dudit ou desdits principes actifs dau moins une partie de la surface dudit comprimé, ledit enrobage étant appliqué de manière à permettre la libération dudit ou desdits principes actifs dudit comprimé après la mise en contact de ladite composition pharmaceutique avec ladite phase aqueuse, établissant une ou plusieurs surfaces de dégradation dudit comprimé; la première dérivée de la zone de chaque surface de dégradation relativement au temps étant supérieure ou égale à zéro.
Bar-Shalom Daniel
Naelapaa Kaisa
Bioneer A/s
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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