Electronic detection of biological molecules using thin layers

G - Physics – 01 – N

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G01N 27/26 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 27/327 (2006.01) G01N 27/403 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2450109

This invention provides novel sensors that facilitate the detection of essentially any analyte. In general, the biosensors of this invention utilize a binding agent (e.g. biomolecule) to specifically bind to one or more target analytes. In preferred embodiments, the biomolecules spans a gap between two electrodes. Binding of the target analyte changes conductivity of the sensor thereby facilitating ready detection of the binding event and thus detection and/or quantitation of the bound analyte.

L'invention a trait à de nouveaux capteurs qui facilitent la détection de sensiblement tout analyte. En général, les biocapteurs de cette invention utilisent un agent liant (<i>p.ex.</i> une biomolécule) de manière à se lier, en particulier, à un ou plusieurs analytes cibles. Dans des modes de réalisation préférés, les biomolécules franchissent un espace entre deux électrodes. La liaison de l'analyte cible change la conductivité du capteur facilitant ainsi détection prête de la liaison et donc la détection et/ou la quantification de l'analyte de liaison.

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