Methods of administering n-substituted benzamides or...

A - Human Necessities – 61 – K

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A61K 31/54 (2006.01) A61K 31/165 (2006.01)

Patent

CA 2182952

A method of administering N-substituted benzamides, phenothiazines and their acid addition salts, in particular metoclopramide and its acid addition salts such as metoclopramide hydrochloride. The metoclopramide or acid addition salt is injected intramuscularly in a formulation with a pH of about 5.5 to about 7.0 and at a concentration of at least about 50 mg/ml, to deliver a dose of one to 5 mg/kg. More generally, the drug is administered either in a formulation containing Na+ ions and at a pH adjusted to reduce extrapyramidal side effects or in a formulation essentially free of Na+ ions.

Procédé d'administration de phénothiazines, de benzamides à substitution N et de leurs sels d'addition d'acide, notamment de métoclopramide et de ses sels d'addition d'acide tels que l'hydrochlorure de métoclopramide. Selon ce procédé, on injecte par voie intramusculaire le métoclopramide ou le sel d'addition d'acide incorporé dans une formulation dont le pH est compris entre environ 5,5 et environ 7,0 et suivant une concentration au moins égale à environ 50 mg/ml, pour distribuer une dose comprise entre 1 et 5 mg/kg. D'une manière plus générale, on administre ce médicament dans une formulation contenant des ions Na?+¿ et présentant un pH réglé pour réduire les effets secondaires extrapyramidaux ou bien dans une formulation essentiellemnt dépourvue d'ions Na?+¿.

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