Refolding and purification of insulin-like growth factor i

Details Refolding and purification of insulin-like growth factor i Refolding and purification of insulin-like growth factor i

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/30 (2006.01) C07K 1/107 (2006.01) C07K 1/113 (2006.01) C07K 14/65 (2006.01) C12N 9/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2109820

2109820 9319084 PCTABS00025 The present invention resides in the refolding of recombinantly produced IGF-I expressed in prokaryotic cells, particularly bacteria, to render biologically active IGF-I, and to methods of isolating correctly refolded IGF-I from incorrectly refolded IGF-I. The present invention also resides in pharmaceutical compositions containing IGF-I and in methods of treating a patient having an IGF associated condition. The present invention also relates to the conversion of met-IGF-I to IGF-I.

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