Prolonged release microcapsules

Details Prolonged release microcapsules Prolonged release microcapsules

A - Human Necessities

61

K

167/166

A61K 9/50 (2006.01) A61K 9/16 (2006.01) A61K 38/06 (2006.01) A61K 38/09 (2006.01)

Patent

CA 2036089

Disclosed is a microcapsule designed for zero order release of a physiologically active polypeptide over a period of at least two months, which is produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing about 20 to 70% (w/w) of the polypeptide and an oil layer containing a polymer having a weight-average molecular weight of 7,000 to 30,000 and a lactic acid/glycolic acid ratio of 80/20 to 100/0, and then subjecting the water-in-oil emulsion to microencapsulation.

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