Pharmaceutical composition containing gp34...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 45/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2272605

A medicinal composition containing a gp34 binding inhibitor as the active ingredient for treating autoimmune diseases including rheumatism, multiple sclerosis, sarcoidosis, autoimmune ophthalmic diseases and inflammatory bowel disease or graft-versus-host disease. It has been experimentally confirmed that the onset of pathological conditions in rheumatism models and multiple sclerosis models can be inhibited by administering an antimouse gp34 rat monoclonal antibody to model mice for inducing collagen arthritis and those for inducing experimental autoimmune encephalomyelitis.

L'invention concerne une composition médicinale dont le principe actif est un inhibiteur de liaison gp34, et qui permet de traiter des maladies auto-immunes comme le rhumatisme, la sclérose en plaques, la sarcoïdose, les maladies ophtalmiques auto-immunes et les maladies intestinales inflammatoires ou encore la réaction du greffon contre l'hôte. On a pu confirmer par des expériences que l'avènement d'états pathologiques dans des modèles de rhumatisme et de sclérose en plaques pouvait être inhibé par l'administration d'un anticorps monoclonal murin antisouris de type gp34 à des souris modèles, dans le cadre d'une induction d'arthrite collagénique et d'une induction expérimentale d'encéphalo-myélite auto-immune.

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