6-azido-2-fluoropurine and its use in the synthesis of...

Details 6-azido-2-fluoropurine and its use in the synthesis of... 6-azido-2-fluoropurine and its use in the synthesis of...

C - Chemistry, Metallurgy

07

D

C07D 473/40 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2085969

Abstract This invention pertains to novel methods of synthesizing fludarabine, fludarabine phosphate and related nucleoside pharmacologic agents utilizing 6-azido-2-fluoropurine as a novel intermediate. In particular this invention pertains to a synthesis of fludarabine where the relatively low yield fluorination step is done before the costly coupling step.

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