Recombinant proteins of a pakistani strain of hepatitis e...

Details Recombinant proteins of a pakistani strain of hepatitis e... Recombinant proteins of a pakistani strain of hepatitis e...

C - Chemistry, Metallurgy

12

N

C12N 15/51 (2006.01) A61K 39/29 (2006.01) C07K 14/005 (2006.01) C07K 14/08 (2006.01) C12N 5/10 (2006.01) C12N 15/866 (2006.01) C12P 21/02 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2144855

A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.

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