Protein smi on hematopoietic stem cells

Details Protein smi on hematopoietic stem cells Protein smi on hematopoietic stem cells

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/04 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2289727

A protein designated "SM1" has a molecular weight of about 230 kDa protein, as measured by immunoprecipitation and SDS-PAGE. SM1 proteins are present on the surface of human and mouse hematopoietic stem cells, respectively, and on primitive progenitor cells, but are absent from the surfaces of other cells, such as FDC-P1 myeloid progenitor cells, EL4 T-cells, WEHI-3 myelomonocytic cells, and 70Z/3 pre-B lymphoid cells, or from differentiated hematopoietic cells of human cord blood or mouse bone marrow. Anti-SM1 antibody can be employed in making a preparation that is enriched for hematopoietic stem cells.

L'invention porte sur une protéine dite "SM1" d'un poids moléculaire de 230 kDa mesuré par immunoprécipitation et SDS-PAGE. Les protéines SM1 sont présentes à la surface des cellules hématopoïétiques souches de l'homme et de la souris, et sur les cellules ascendantes primitives, mais absentes de la surface des autres cellules telles que les cellules ascendantes FDC-P1 du myloïde, les cellules T EL4, les cellules myélomonocytiques WEHI-3 et des cellules lymphoïdes pré-B, ou l es cellules hématopoïétiques prédifférenciées du sang de la moelle épinière humaine ou de la moelle de souris. Les anticorps anti SM1 peuvent servir à élaborer une préparation enrichie en cellules hématopoïétiques souches.

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