Prodrugs of mitotic kinesin inhibitors

Details Prodrugs of mitotic kinesin inhibitors Prodrugs of mitotic kinesin inhibitors

C - Chemistry, Metallurgy

07

D

C07D 231/06 (2006.01) A61K 31/415 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2571821

The present invention relates to prodrugs of dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

L'invention concerne des bioprécurseurs de composés d'hydropyrazole servant à traiter maladies prolifératives cellulaires, à traiter les troubles associées à l'activité KSP (Kinesin spindle protein: protéine-kinase fusiforme) de la kinésine, et à inhiber la KSP. L'invention se rapporte également à des compositions qui contiennent ces composés, et à des méthodes consistant utiliser ces compositions pour le traitement des cancers chez les mammifères.

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