Polycyclic xanthones as antibiotics

Details Polycyclic xanthones as antibiotics Polycyclic xanthones as antibiotics

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 31/7048 (2006.01) A61P 35/00 (2006.01) C07D 493/04 (2006.01) C07H 15/24 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2412559

A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus <i>Actinomadura sp.</i>), of a compound designated IB-00208. The class of the formulae (I) or (II) where R1 can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R2 and R3 can be hydrogen, alkyl, or together R2 and R3 form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.

Une nouvelle classe de composés antitumoraux a été reconnue grâce à l'isolation à partir d'un nouveau microbe marin de souche PO13-046 appartenant au genre Actinomadura d'un composé désigné IB-00208. La classe correspond à la formule (I) ou (II), dans laquelle R1 peut être hydrogène, acyle, alkyle, alcényle, aryle, benzyle, métal alcalin et/ou sucre, et R2 et R3 peuvent être hydrogène, alkyle, R2 et R3 pouvant former ensemble une liaison insaturée. Ces composés manifestent une activité intéressante contre plusieurs lignées cellulaires et contre les bactéries à gram positif.

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