Phosphorylated cop1 molecules and uses thereof

Details Phosphorylated cop1 molecules and uses thereof Phosphorylated cop1 molecules and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/25 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2635756

The invention provides COP1 molecules and modulators of COP1 activity and methods of using them, including diagnostic and therapeutic uses thereof. Such molecules can be useful for detecting DNA damage and modulating the response to DNA damage and p53 activity in subjects. The invention also provides reagents and kits for use in screening for test compounds that can modulate COP1 activity.

L'invention concerne des molécules de COP1 et des modulateurs de l'activité du COP1, ainsi que des procédés pour les utiliser, y compris leurs utilisations diagnostiques et thérapeutiques. Ces molécules peuvent être utiles pour détecter la dégradation d'ADN et moduler la réponse à la dégradation de l'ADN et à l'activité de la p53 chez les sujets. L'invention concerne également des réactifs et des kits utilisables pour cribler des composés de test capables de moduler l'activité du COP1.

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