Therapeutic agent/ligand conjugate compositions, their...

Details Therapeutic agent/ligand conjugate compositions, their... Therapeutic agent/ligand conjugate compositions, their...

A - Human Necessities

61

K

A61K 31/704 (2006.01) A61K 31/337 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01)

Patent

CA 2444383

Conjugate molecules comprising a ligand or targeting moiety bonded to a polymer spacer, a polymer carrier bonded to the polymer spacer, and a therapeutic agent bound to the polymer carrier (with or without a linker) are disclosed. The conjugate molecules are useful for the selective delivery of therapeutic agents to tumors or other tissues expressing biological receptors.

L'invention concerne des molécules conjuguées qui comprennent un ligand ou fraction de ciblage lié à un espaceur de polymère, un support de polymère lié à l'espaceur de polymère et un agent thérapeutique lié au support de polymère (avec ou sans lieur). Ces molécules conjuguées conviennent pour l'administration sélective d'agents thérapeutiques à des tumeurs ou à d'autres tissus exprimant des récepteurs biologiques.

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