Indol-2-ones as selective inhibitors of cyclooxygenase-2

Details Indol-2-ones as selective inhibitors of cyclooxygenase-2 Indol-2-ones as selective inhibitors of cyclooxygenase-2

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/404 (2006.01) A61P 29/00 (2006.01) C07D 401/06 (2006.01)

Patent

CA 2484017

The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula (I) pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The compounds of the invention are particularly useful in the treatment or alleviation of inflammation and inflammation associated disorders, such as, for example, rheumatoid arthritis and osteoarthritis, and in the relief of pain, such as, for example, pain associated with surgery or trauma, in mammals. preferably felines and canines.

La présente invention concerne des inhibiteurs sélectifs de la cyclooxygénase-2 (COX-2), de formule (I), des compositions pharmaceutiques contenant ces inhibiteurs, leur utilisation à des fins thérapeutiques et leurs préparations. Ces composés sont particulièrement utiles pour traiter ou atténuer des inflammations ou des troubles associés à des inflammations, tels que l'arthrite rhumatoïde et l'ostéoarthrite, et pour soulager la douleur, notamment la douleur associée à une intervention chirurgicale ou un trauma, chez les mammifères, de préférence les félidés et les canidés.

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