Respiratory syncytial virus vaccine based on chimeric...

Details Respiratory syncytial virus vaccine based on chimeric... Respiratory syncytial virus vaccine based on chimeric...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 9/00 (2006.01) A61K 39/155 (2006.01) C07K 14/025 (2006.01) C07K 14/135 (2006.01) C07K 19/00 (2006.01) C12N 7/01 (2006.01) C12N 15/34 (2006.01) C12N 15/45 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2703066

The present invention is directed to a chimeric papillomavirus virus- like particle (VLP) or capsomere including an L1 polypeptide and, optionally, an L2 polypeptide, and a respiratory syncytial virus (RSV) protein or polypeptide fragment thereof comprising a first epitope, where the RSV protein or polypeptide fragment thereof is attached to one or both of the L1 and L2 polypeptides. Chimeric proteins, genetic constructions, and recombinant vectors and host cells suitable for expression of the constructs and making of the chimeric VLPs or capsomeres are also disclosed. Use of the VLPs or capsomeres, or a pharmaceutical composition containing the same, is contemplated for inducing a protective immune response against RSV.

La présente invention concerne un capsomère ou une particule chimérique semblable au virus du papillomavirus (VLP) incluant les éléments suivants : un polypeptide Ll et, éventuellement, un polypeptide L2, et une protéine du virus syncytial respiratoire (VSR) ou un fragment de polypeptide de celle-ci comprenant un premier épitope. La protéine de VSR ou le fragment de polypeptide de celle-ci est fixé à l'un des polypeptides Ll et L2 ou aux deux. L'invention concerne également des protéines chimériques, des structures génétiques, ainsi que des vecteurs recombinants et des cellules hôtes adaptées à l'expression des structures et à la réalisation des VLP ou des capsomères chimériques. L'utilisation des VLP ou des capsomères, ou d'une composition pharmaceutique les contenant, est envisagée pour l'induction d'une réponse immune protectrice contre le VSR.

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