Tetracyclic indole derivatives as 5-ht receptor ligands

Details Tetracyclic indole derivatives as 5-ht receptor ligands Tetracyclic indole derivatives as 5-ht receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 495/18 (2006.01) A61K 31/495 (2006.01) A61K 31/4985 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) A61P 25/24 (2006.01) C07D 471/16 (2006.01) C07D 487/06 (2006.01) C07D 487/16 (2006.01) C07D 491/16 (2006.01) C07D 495/16 (2006.01)

Patent

CA 2453343

The present invention provides compounds of formula (I) , wherei n R1, R2, R3, R4, Y, b, and c have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds. The invention also provides therapeutic methods for treating diseases wherein modulation of 5-HT activity is desired, as well as processes and intermediates useful for preparing compounds of formula I.

La présente invention concerne des composés représentés par la formule (I), où R¿1?, R¿2?, R¿3?, R¿4?, Y, b et c ont n'importe laquelle des valeurs indiquées dans le descriptif, ainsi que des compositions pharmaceutiques contenant lesdits composés. L'invention a également trait à des méthodes thérapeutiques permettant de traiter des maladies par modulation de l'activité de 5-HT, ainsi qu'à des procédés et à des intermédiaires permettant de préparer les composés représentés par la formule (I).

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