A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61K 38/07 (2006.01)
Patent
CA 2484994
This invention is drawn to methods of using peptide-based antagonists of TGF- beta to facilitate the healing of cutaneous wounds that includes burns, lacerations and scrapes. The administration of peptide TGF-beta antagonists to wounds results in reduced scarring, wound contraction and deposition of extracellular matrix components, and increased rates of re-epithelialiation during wound healing.
L'invention se rapporte à des procédés d'utilisation d'antagonistes peptidiques du TGF-bêta dans le but de faciliter la cicatrisation de plaies cutanées, notamment de brûlures, de lacérations et d'écorchures. L'administration à des plaies d'antagonistes peptidiques du TGF-bêta permet de réduire la formation de cicatrices, la contraction des plaies et le dépôt de composants matriciels extracellulaires, et elle permet également d'accroître les taux de ré-épithélialisation lors de la cicatrisation des plaies.
Mcfadden Fincham
St. Louis University
LandOfFree
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