Inhibition of oncogene transcription by synthetic polyamides

Details Inhibition of oncogene transcription by synthetic polyamides Inhibition of oncogene transcription by synthetic polyamides

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) C07D 207/34 (2006.01) C07D 233/90 (2006.01)

Patent

CA 2342278

Polyamides capable of inhibiting the transcription of oncogenes are provided. Preferred polyamides comprising at least three complementary pairs of aromatic carboxamide residues bind in the minor groove of double-stranded DNA. With regard to each polyamide, the complementary pairing of some or all of the polyamide's aromatic carboxamide residues determines the target nucleotide sequence of an identified dsDNA target in the promoter region of an oncogene.

L'invention concerne des polyamides capables d'inhiber la transcription d'oncogènes. De préférence, les polyamides comprennent au moins trois paires complémentaires de résidus de carboxamides aromatiques se liant au sillon mineur d'un ADN à double brin. En ce qui concerne chaque polyamide, l'appariement complémentaire de quelques-uns ou de la totalité des résidus de carboxamides aromatiques du polyamide détermine la séquence nucléotidique cible d'une cible d'ADN à double brin identifiée dans la région d'activation d'un oncogène.

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