A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/195 (2006.01) C12N 9/00 (2006.01)
Patent
CA 2691623
Provided herein are methods for treating a subject suffering from phenylketonuria by administering a phenylalanine hydroxylase ("PAH") and/or a phenylalanine ammonia lyase ("PAL") to the subject under conditions effective to deliver the pheny-lalanine 4-hydroxylase and/or PAL to the subject's small intestine. Also provided are methods for increasing the therapeutic activity of a phenylalanine 4-hydroxylase by thiolating the phenylalanine 4- hydroxylase. In addition, provided are oral dosage forms that include a phenylalanine 4-hydroxylase and/or a PAL and an enteric coating.
Méthodes de traitement d'un sujet souffrant de phénylcétonurie au moyen de phénylalanine hydroxylase ("PAH") et/ou de phénylalanine ammonia lyase ("PAL") dans des conditions efficaces pour l'administration de la phénylalanine 4-hydroxylase et/ou de PAL dans l'intestin grêle dudit sujet. L'invention concerne également des méthodes propres à accroître l'activité thérapeutique de la phénylalanine 4-hydroxylase par thiolation de cette dernière. Sont également décrites des formes racémiques orales comprenant une phénylalanine 4-hydroxylase et/ou PAL et un enrobage gastrorésistant.
Borden Ladner Gervais Llp
The Board Of Regents Of The University Of Texas System
LandOfFree
Methods and compositions for treating phenylketonuria does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for treating phenylketonuria, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for treating phenylketonuria will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1879455