Osteoprotegerin binding proteins and receptors

Details Osteoprotegerin binding proteins and receptors Osteoprotegerin binding proteins and receptors

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61P 19/00 (2006.01) G01N 33/566 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2706609

A novel polypeptide, osteoprotegerin binding protein, involved in osteoclast maturation has been identified based upon its affinity for osteoprotegerin. Nucleic acid sequences encoding the polypeptide, or a fragment, analog or derivative thereof, vectors and host cells for production, methods of preparing osteoprotegerin binding protein, and binding assays are also described. Compositions and methods for the treatment of bone diseases such as osteoporosis, bone loss due to arthritis or metastasis, hypercalcemia, and Paget's disease are also provided. Receptors for osteoprotegerin binding proteins are also described. The receptors, and agonists and antagonists thereof, may be used to treat bone diseases.

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