Predictive methods for cancer chemotherapy

G - Physics – 01 – N

Patent

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G01N 33/574 (2006.01)

Patent

CA 2616874

This invention provides methods and reagents for determining or predicting responses to cancer therapy, as well as dual therapy treatments. The methods involve identifying mammalian tumors that can be treated with dual mTOR pathway inhibitor and EGF pathway inhibitor therapy, comprising the step of assaying a sample from the tumor to detect expression and/or phosphorylation of polypeptides of the EGF pathway and of the mTOR pathway. EGF pathway polypeptides may include ERK and MEK, while mTOR pathway polypeptides may include mTOR and/or HIF-I alpha .

L'invention concerne des méthodes et des réactifs permettant de déterminer ou de prédire la réponse à une thérapie cancéreuse ainsi que des traitements thérapeutiques double.

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