Calmodulin independent activation of nitric oxide synthase...

C - Chemistry – Metallurgy – 12 – N

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C12N 9/02 (2006.01) A61K 31/7052 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2505118

Methods for activation of a constitutive nitric oxide synthase are described, as are agents which activate a constitutive nitric oxide synthase (e.g., NADPH analogs), methods of identifying such agents, and methods of treatment of diseases or conditions associated with nitric oxide production by a constitutive nitric oxide synthase, by administering an agent which activates the constitutive nitric oxide synthase.

L'invention concerne des procédés d'activation d'une oxyde nitrique synthase constitutive, et agents activant une oxyde nitrique synthase constitutive (p.ex. analogues NADPH), des procédés d'identification de tels agents et des méthodes de traitement de maladies ou d'états pathologiques associé(e)s à la production d'oxyde nitrique au moyen d'une oxyde nitrique synthase constitutive, par administration d'un agent activant l'oxyde nitrique synthase constitutive.

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