Micronized vitamin c formulation

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61K 8/04 (2006.01) A61K 8/37 (2006.01) A61K 8/64 (2006.01) A61K 8/67 (2006.01) A61Q 17/04 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2402009

Stable vitamin C (L-ascorbic acid) compositions for topical application, comprising micronized L-ascorbic acid in a substantially non-aqueous carrier having a pH greater than that of skin, and preferably not lower than approximately 5.5 and not greater than approximately 7.5, are described. The composition may consist essentially of L-ascorbic acid and capric/caprylic triglycerides or may further comprise papain as an enzymatic exfoliant in addition to humectants, emollients, viscosity-increasing agents, surfactants, and preservatives. Methods of preparing the micronized L-ascorbic acid for use in the described formulations, by a "wet" micronization process, are also described. The compositions are useful as UV protectants, promoters of collagen synthesis and in the removal and/or treatment of wrinkles.

L'invention concerne des compositions stables de vitamine C (acide L-ascorbique) destinées à une application topique, comprenant de l'acide L-ascorbique microfin dans un excipient sensiblement non aqueux possédant un pH supérieur à celui de la peau et, de préférence, compris entre environ 5,5 et 7,5. La composition peut être constituée essentiellement d'acide L-ascorbique et de triglycérides capriques/capryliques, ou bien elle peut également contenir de la papaïne comme exfoliant enzymatique, s'ajoutant à des humectants, des émollients, des agents améliorant la viscosité, des tensioactifs et des conservateurs. L'invention concerne également des méthodes de préparation de l'acide L-ascorbique microfin et d'utilisation dans les formulations décrites, grâce à un procédé de micronisation <= mouillée >=. ces compositions sont utiles comme agents protecteurs contre les UV, promoteurs de la synthèse de collagène, ainsi que dans l'élimination et/ou le traitement des rides.

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