Differential labeling of cells

Details Differential labeling of cells Differential labeling of cells

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/02 (2006.01) C12N 5/10 (2006.01) C12N 15/65 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) C40B 30/06 (2006.01)

Patent

CA 2660321

The invention relates to the generation of an animal model that exhibits neural cell-specific expression of a marker gene that correlates to remyelination or myelin repair. The compositions and methods embodied in the present invention are particularly useful for drug screening and/or treatment of demyelination disorders, particularly in identifying compounds that promote or inhibit remyelination.

La présente invention concerne la génération d'un modèle animalier qui illustre l'expression spécifique de cellules neurales d'un gène marqueur correspondant à une remyélination ou une réparation de la myéline. Les compositions et procédés faisant l'objet de la présente invention se révèlent particulièrement utiles pour le criblage de médicaments et/ou le traitement de troubles de démyélination, particulièrement pour identifier des composés qui favorisent ou inhibent la remyélination.

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