Peptide and adsorbent thereof immobilized on carrier

Details Peptide and adsorbent thereof immobilized on carrier Peptide and adsorbent thereof immobilized on carrier

C - Chemistry, Metallurgy

07

K

530/17, 530/7.08

C07K 17/00 (2006.01) B01J 20/32 (2006.01) C07K 7/08 (2006.01) C07K 14/715 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2026881

- 1 - Abstract The present invention provides a peptide capable of binding to interleukin 6, represented by the general formula: H-X-A-Y-Z (I) wherein A is a peptide segment formed by binding 6 to 50 amino acids; each of X and Y is a single bond or an amino acid residue selected from the group consisting of Asp, Glu, Lys, Ala and a divalent group of the formula: -NH(CH2)n-CO- (wherein n is an integer of 1 to 17), or a peptide segment composed of 2 to 10 amino acid residues selected from the above group which are bound to each other through a peptide bond; Z is a hydroxyl group or an amino group. The invention further provides an adsorbent for interleukin 6 comprising the peptide immobilized on a carrier. The peptide of the present invention having interleukin 6 bound thereto is suitable for use in the treatment of autoimmune diseases.

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