Differentiation of neural stem cells and therapeutic use...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/0797 (2010.01) A61K 31/565 (2006.01) A61K 35/12 (2006.01) A61K 35/30 (2006.01) A61K 38/18 (2006.01) A61K 38/22 (2006.01) A61K 38/27 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2458261

This invention relates to a method of selectively producing neural cells, including neurons or glial cells, in vitro orin vivo. Also provided are methods of treating or ameliorating neurodegenerative disease or medical conditions by producing neural cells. Thus, a combination of factors is used to achieve two steps: increasing the number of neural stem cells and instructing the neural stem cells to selectively become neurons or glial cells.

Cette invention porte sur un procédé visant à produire sélectivement, in vitro ou in vivo, des cellules neurales telles que les neurones ou les cellules gliales. L'invention porte également sur des procédés visant à traiter ou à apporter une amélioration à des états pathologiques ou des maladies neurodégénératives en produisant des cellules neurales. On peut ainsi utiliser une combinaison de facteurs pour réaliser deux étapes : augmenter le nombre de cellules souches neurales et soumettre ces cellules souches neurales à des conditions appropriées pour qu'elles deviennent sélectivement des neurones ou des cellules gliales.

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