Use of antagonist anti-cd40 antibodies for treatment of...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61P 35/02 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2544364

Methods of therapy for treating a subject for chronic lymphocytic leukemia are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen- binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40- expressing cell. Antagonist activity of the anti-CD40 antibody or antigen- binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing chronic lymphocytic leukemia cells.

L'invention porte sur des thérapies de traitement d'un sujet atteint de leucémie lymphocytique chronique. Ces procédés consistent à administrer une quantité thérapeutiquement efficace d'un anticorps anti-CD40 antagoniste ou d'un fragment à liaison antigène à un patient qui en a besoin. L'anticorps anti-CD-40 antagoniste ou le fragment à liaison antigène ne présente pas d'activité agoniste significative, mais présente une activité antagoniste lorsque l'anticorps se lie à un antigène CD40 sur une cellule d'expression CD40 humaine. L'activité antagoniste de l'anticorps anti-CD40 ou du fragment à liaison antigène inhibe de manière bénéfique la prolifération et/ou la différenciation des cellules de la leucémie lymphocytique chronique d'expression CD40 humaine.

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