Modified erythropoietin (epo) with reduced immunogenicity

Details Modified erythropoietin (epo) with reduced immunogenicity Modified erythropoietin (epo) with reduced immunogenicity

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 9/70 (2006.01) A61K 38/18 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/505 (2006.01) C07K 14/54 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/09 (2006.01) A61K 38/00 (2006.01) A61K 38/11 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2437272

The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The inention in particular relates to the modification of erythropoietin (EPO) to result in erythropoietin proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

La présente invention concerne des polypeptides à administrer notamment à des sujets humains et en particulier pour une utilisation thérapeutique. Les polypeptides sont des polypeptides modifiés de telle manière que la modification a pour résultat une propension réduite à la mise en lumière d'une réponse immune par le polypeptide, lors de l'administration au sujet humain. L'invention concerne notamment la modification d'érythropoïétine (EPO) afin d'obtenir des protéines d'érythropoïétine sensiblement non immunogènes ou moins immunogènes que n'importe quel homologue non identifié lors d'une utilisation <i>in vivo.</i>

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