C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/48 (2006.01) A61K 31/421 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2534529
The present invention relates to compounds of the Formula (I), wherein R3, R5, R6, R7, and Z, and other variables enumerated under one or more of R3, R5, R6, R7, and Z, are as defined. Compounds of the Formula (I) have activity inhibiting production of A.beta.-peptide. This invention also relates to pharmaceutical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g.. Alzheimer~s disease, in a mammal comprising compounds of the Formula (I).
L'invention concerne des composés de formule (I), dans laquelle R?3¿, R?5¿, R?6¿, R?7¿ et Z, ainsi que les autres variables énumérées relativement à R?3¿, R?5¿, R?6¿, R?7¿ et/ou Z, sont tels que définis. Ces composés de formule (I) possèdent une activité inhibant la production d'A.beta.-peptide. L'invention concerne également des compositions pharmaceutiques et des méthodes de traitement de maladies, par exemple de maladies neurodégénérescentes telles que la maladie d'Alzheimer, chez un mammifère, ces compositions et ces méthodes faisant intervenir des composés de formule (I).
Pfizer Products Inc.
Torys Llp
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