Substituted isoquinoline and isoquinolinone derivatives

Details Substituted isoquinoline and isoquinolinone derivatives Substituted isoquinoline and isoquinolinone derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4725 (2006.01) A61P 9/00 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2673918

The invention relates to 6-substituted isoquinoline and isochinolone derivatives of the formula (I) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.

L'invention concerne des dérivés d'isoquinoline et d'isoquinolone 6-substitués représentés par la formule (I), utilisés dans le traitement et/ou la prévention de maladies associées à la Rho-kinase et/ou à la phosphorylation médiée par la Rho-kinase de la phosphatase de la chaîne légère de la myosine, et des compositions contenant lesdits composés.

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