Use of amino acids for treatment of various conditions

A - Human Necessities – 61 – K

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A61K 31/20 (2006.01) A61K 31/196 (2006.01) A61K 31/198 (2006.01)

Patent

CA 2490308

A method of treating a patient for a condition characterized by symptoms that can be alleviated by interfering with or supplementing the activity of endogenous ligands on the a2S subunit of a voltage gated calcium channel, said method comprising: administering to a patient experiencing the condition an amount of one or more of L-norleucine, L-isoleucine, L-alloisoleucine, L- methionine, L~leucine, 2-cyclohexylglycine, 2-phenylglycine, 2-amino-2- norbomane carboxylic acid, 1-aminocyclohexane carboxylic acid, 2- aminoheptanoic acid, 2-aminocaprylic acid, and 2-aminononanoic acid under conditions effective to treat the condition, wherein when the condition is a hot flash or a symptom of hormonal variation, the compound is not L-leucine.

L'invention concerne une méthode permettant de traiter un patient atteint d'une affection caractérisée par des symptômes pouvant être soulagés par perturbation ou renforcement de l'activité de ligands endogènes sur la sous-unité .alpha.¿2?.delta. d'un canal calcique dépendant du voltage. Cette méthode consiste à administrer à un patient atteint d'une affection une quantité de l'un ou de plusieurs des éléments parmi lesquels la L-norleucine, la L-isoleucine, la L-alloisoleucine, la L-méthionine, la L-leucine, la 2-cyclohexylglycine, la 2-phénylglycine, l'acide carboxylique 2-amino-2-norbomane, l'acide carboxylique 1-aminocyclohexane, l'acide 2-aminoheptanoïque, l'acide 2-aminocaprylique, et l'acide 2-aminononanoïque dans des conditions permettant de traiter cette affection; lorsque cette affection consiste en une bouffée de chaleur ou en un symptôme lié à la modification hormonale, le composé n'est pas la L-leucine.

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