Pooled cord blood units

A - Human Necessities – 61 – K

Patent

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Details

IPC codes

A61K 35/44 (2006.01) C12N 5/073 (2010.01) A61K 35/14 (2006.01) C12N 5/0789 (2010.01) A61M 5/14 (2006.01)

Type

Patent

Patent number

CA 2703428

Description

A pharmaceutical composition comprising hematopoietic stem cells isolated from pooled umbilical cord blood from separate donors, which can be infused in a patient in need of an umbilical cord blood transplant to increase the speed and success of engraftment. A method and a pooling criteria for minimizing lysis of total nucleated cells in pooled umbilical cord blood from separate donors is also provided. The method involves considering the ABO blood types of the donors of the umbilical cord blood units to be pooled as well as the ABO blood type of the respective mothers. The present invention also provides a means for increasing the availability of cord blood transplants to adults or individuals greater than 65 or 70 kilograms.

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