Avirulent microbes and uses therefor

Details Avirulent microbes and uses therefor Avirulent microbes and uses therefor

C - Chemistry, Metallurgy

12

N

167/135, 195/34.

C12N 1/20 (2006.01) A61K 39/112 (2006.01) C12N 15/00 (2006.01) C12N 15/74 (2006.01)

Patent

CA 2013572

-34- ABSTRACT OF THE DISCLOSURE This invention provides a vaccine for the im- munization of a vertebrate or invertebrate comprising an avirulent derivative of S. choleraesuis. The derivatives being substantially incapable of producing functional adenylate cyclase and/or cyclic AMP receptor protein. The invention also provides a vaccine for the immunization of a vertebrate and invertebrate comprising a virulent derivative of a pathogenic microbe said derivative being substantially incapable of producing functional adenylate cyclase and/or cyclic AMP receptor protein while being capable of expressing a recombinant gene derived from a pathogen of said vertebrate to produce an antigen capable of inducing an immune response in said vertebrate against said pathogen.

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