C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/88 (2006.01) C12N 5/071 (2010.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/89 (2006.01)
Patent
CA 2743668
The present invention includes compositions and methods for regenerating glucose-responsive cells by ultrasound-targeted microbubble destruction in the pancreas, wherein the composition comprises a pre-assembled liposome-nucleic acid complex in contact with within and about a microbubble, wherein the pre- assembled liposome-nucleic acid complex comprises a NeuroD gene under the control of the promoter, wherein disruption of the microbubble in the pancreas at a target site delivers the nucleic acid into pancreas cells at the location of the ultrasound disruption, wherein cells that incorporate the nucleic acid express insulin in response to high blood glucose levels.
La présente invention concerne des compositions et des procédés pour régénérer des cellules répondant au glucose par destruction dune microbulle ciblée par ultrasons dans le pancréas, où la composition comprend un complexe liposome-acide nucléique préassemblé en contact dans et autour dune microbulle, où le complexe liposome-acide nucléique préassemblé comprend un gène NeuroD sous le contrôle du promoteur, où la rupture de la microbulle dans le pancréas à un site cible délivre lacide nucléique dans les cellules du pancréas à lemplacement de la rupture par ultrasons, où les cellules qui incorporent lacide nucléique expriment de linsuline en réponse à des taux de glycémie élevés.
Chen Shuyuan
Ding Jiahuan
Grayburn Paul A.
Baylor Research Institute
Shapiro Cohen
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