Sustained release drug delivery system containing codrugs

Details Sustained release drug delivery system containing codrugs Sustained release drug delivery system containing codrugs

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/00 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 31/192 (2006.01) A61K 31/513 (2006.01) A61K 31/58 (2006.01) A61L 29/16 (2006.01) A61L 31/10 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2444894

Disclosed is a sustained release system that includes a polymer and a prodrug having a solubility less than about 1 mg/ml dispersed in the polymer. Advantageously, the polymer is permeable to the prodrug and may be non-release rate limiting with respect to the rate of release of the prodrug from the polymer. This permits improved drug delivery within a body in the vicinity of a surgery via sustained release rate kinetics over a prolonged period of time, while not requiring complicated manufacturing processes.

La présente invention concerne un système de libération continue qui comprend un polymère et un promédicament possédant une solubilité inférieure à environ 1 mg/ml dispersé dans ce polymère. Ce polymère présente l'avantage d'être perméable au promédicament et il peut être non limiteur de vitesse de libération par rapport à la vitesse de libération du promédicament en provenance de ce polymère. Ceci permet d'améliorer la distribution du médicament dans l'anatomie dans les environs d'une implantation chirurgicale via une cinétique de vitesse de libération continue pendant une durée prolongée, sans nécessiter de processus de fabrication compliqués.

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