C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/70 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2281903
A method is disclosed for inhibiting malignant neoplastic growth of epithelial or endothelial cells in a mammal by administering to the mammal an effective amount of an oligonucleotide complementary to at least a portion of mRNA for ERK-1 or ERK-2 that is overexpressed in the mammal. The antisense oligonucleotides are administered to the mammal as a dosage unit. A method of identifying and monitoring potentially malignant neoplastic cell growth in a mammal is also disclosed.
L'invention concerne un procédé inhibant la croissance maligne néplasique de cellules épithéliales ou endothéliales chez un mammifère, grâce à l'administration à ce mammifère d'une quantité efficace d'un oligonucléotide, complémentaire d'au moins une partie de l'ARN messager de ERK-1 ou ERK-2, surexprimé dans ledit mammifère. Les oligonucléotides anti-sens sont administrés à ce mammifère sous forme d'unité posologique. L'invention concerne également un procédé d'identification et de contrôle d'une croissance cellulaire néplasique potentiellement maligne chez un mammifère.
Malbon Craig C.
Sivaraman Vimala S.
Wang Hsien-Yu
Smart & Biggar
The Research Foundation Of State University Of New York
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