Method for genetically modifying bone marrow cells of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/15 (2006.01) C12N 5/10 (2006.01) C12N 9/78 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2120370

2120370 9307281 PCTABS00021 A method for genetically modifying bone marrow cells of primates, comprising isolating bone marrow cells from a primate and, by means of cocultivation, exposing the isolated bone marrow cells to cells that produce a recombinant amphotropic retrovirus with a genome based on a retroviral vector that contains the genetic information to be introduced into the bone marrow cells. Recombinant amphotropic retrovirus-producing cells, suitable for use in this method.

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