Influenza vaccines with increased amounts of h3 antigen

Details Influenza vaccines with increased amounts of h3 antigen Influenza vaccines with increased amounts of h3 antigen

A - Human Necessities

61

K

A61K 39/145 (2006.01)

Patent

CA 2752041

An influenza vaccine includes an increased amount of H3N2 antigen relative to the normal dose. In a typical em-bodiment, the vaccine includes hemagglutinins from an A/H1N1 strain, an A/H3N2 strain, and a B strain, wherein (i) the weight ratio of H3N2:H1N1 hemagglutinin is greater than 1 and (ii) the weight ratio of H3N2:B hemagglutinin is greater than 1. In such a vaccine the weight ratio of H1N1 :B hemagglutinin will normally be 1. For example, a vaccine may contain hemagglutinin at 15µg for A/H1N1, 30µg for A/H3N2 and 15µg for B.

La présente invention concerne un vaccin contre l'influenza comprenant une quantité accrue d'antigène H3N2 par rapport à la dose normale. Dans un mode de réalisation typique, ledit vaccin comprend des hémagglutinines provenant d'une souche A/H1N1, d'une souche A/H3N2, et d'une souche B, (i) le rapport pondéral des hémagglutinines H3N2/H1N1 étant supérieur à 1 et (ii) le rapport pondéral des hémagglutinines H3N2/B étant supérieur à 1. Dans un tel vaccin, le rapport pondéral des hémagglutinines H1N1/B est normalement égal à 1. Par exemple, le vaccin peut contenir des hémagglutinine à 15 µg pour A/H1N1, 30 µg pour A/H3N2 et 15 µg pour B.

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