A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4745 (2006.01) A61K 31/4741 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2454627
The present invention relates to the use of irinotecan or derivative thereof for the preparation of a pharmaceutical composition for treating cancer, especially, colorectal cancer, cervical cancer, gastric cancer, lung cancer, malignant glioma, ovarian cancer, and pancreatic cancer in a patient having a genotype with a variant allele which comprises a polynucleotide in accordance with the present invention. Preferably, a nucleotide deletion, addition and/or substitution comprised by said polynucleotide results in an altered expression of a variant allele compared to the corresponding wild type allele or an altered activity of the polypeptide encoded by the variant allele compared to the polypeptide encoded by the corresponding wild type allele. Finally, the present invention relates to a method for selecting a suitable therapy for a subject suffering from colorectal cancer, cervical cancer, gastric cancer, lung cancer, malignant glioma, ovarian cancer, and pancreatic cancer.
La présente invention concerne l'utilisation de l'irinotecan ou de ses dérivés pour la préparation d'une composition pharmaceutique destinée à traiter le cancer, notamment le cancer colorectal, le cancer du col utérin, le cancer de l'estomac, le cancer du poumon, le gliome malin, le cancer de l'ovaire et le cancer du pancréas chez un patient dont le génotype a un allèle variant contenant un polynucléotide conforme à la présente invention. De préférence, la délétion, l'addition et/ou la substitution des bases contenues dans ce polynucléotide se traduit/traduisent par une expression altérée d'un allèle variant par rapport à l'allèle de type sauvage correspondant ou à une activité altérée du polypeptide codé par l'allèle variant par rapport au polypeptide codé par l'allèle de type sauvage correspondant. L'invention concerne enfin un procédé de sélection d'une thérapie adaptée pour un patient souffrant du cancer du colorectal, du cancer du col utérin, du cancer de l'estomac, du cancer du poumon, du gliome malin, du cancer de l'ovaire et du cancer du pancréas.
Heinrich Guenther
Kerb Reinhold
Epidauros Biotechnologie Ag
Smart & Biggar
LandOfFree
Methods for improved treatment of cancer with irinotecan... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for improved treatment of cancer with irinotecan..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for improved treatment of cancer with irinotecan... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1886301