Vertebrate apoptosis gene: compositions and methods

Details Vertebrate apoptosis gene: compositions and methods Vertebrate apoptosis gene: compositions and methods

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/435 (2006.01) C07K 14/465 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2165969

The invention relates generally to compositions of and methods for obtain- ing and using a polypeptide other than BCL-2 (SEQ ID NO.5) that affects pro- grammed vertebrate cell death. The in- vention relates as well to polynucleotides encoding those polypeptides, recombi- nant vectors carrying those sequences, the recombinant host cells including ei- ther the sequences or vectors, and re- combinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in as says designed to select and improve sub- stances capable of altering programmed cell death for use in diagnostic, drug de- sign and therapeutic applications.

Compositions de polypeptide autre que BCL-2 (SEQ ID NO:5) qui affecte la mort cellulaire programmée chez les vertébrés et procédés d'obtention et d'utilisation dudit polypeptide. La présente invention concerne également des polynucléotides codant ces polypeptides, des vecteurs de recombinaison portant ces séquences, les cellules hôtes de recombinaison comprenant lesdites séquences ou lesdits vecteurs, et de polypeptides de recombinaison. La présente invention présente en outre des procédés d'utilisation des polypeptides isolés recombinés dans des analyses destinées à sélectionner et à améliorer des substances capables de modifier la mort cellulaire programmée en vue d'applications diagnostiques, pharmacologiques et thérapeutiques.

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