Method for quantitatively determining the ldl particle...

G - Physics – 01 – N

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G01N 33/92 (2006.01)

Patent

CA 2624023

The invention provides a method (e.g., a computer algorithm) for calculating a number of particles in a LDL subfraction. The method features the steps of: 1) measuring an initial distribution of LDL particles (e.g., a relative mass distribution) from a blood sample; 2) processing the initial distribution of LDL particles with a mathematical model to determine a modified distribution of LDL particles (e.g., a relative particle distribution); 3) determining a total LDL particle number value from a blood sample; and 4) analyzing both the modified distribution of particles and the total LDL particle number value to calculate the particle number value in an LDL subfraction.

L~invention concerne un procédé (par exemple, un algorithme informatique) permettant de calculer un nombre de particules dans une sous-fraction LDL. Le procédé comprend les phases suivantes : 1) mesure d~une distribution initiale des particules LDL (par exemple, une distribution de masse relative) à partir d~un prélèvement sanguin ; 2) traitement de la distribution initiale de particules LDL avec un modèle mathématique afin de déterminer une distribution modifiée de particules LDL (par exemple, une distribution de particules relative) ; 3) détermination d~une valeur totale du nombre de particules LDL à partir d~un prélèvement sanguin ; et 4) analyse à la fois de la distribution modifiée des particules et de la valeur totale du nombre de particules LDL afin de calculer la valeur du nombre de particules dans une sous-fraction LDL.

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