Methods for improving protein performance

Details Methods for improving protein performance Methods for improving protein performance

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C12N 15/01 (2006.01) C12N 15/52 (2006.01)

Patent

CA 2690055

The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for altering the net surface charge and/or surface charge distribution of enzymes {e.g., metalloproteases or serine proteases) to obtain enzyme variants that demonstrate improved performance in detergent formulations as compared to the starting or parent enzyme.

La présente invention concerne des procédés visant à mettre au point des protéines pour optimiser leurs performances dans certaines conditions environnementales d'intérêt. Selon certains modes de mise en oeuvre, la présente invention concerne des procédés visant à mettre au point des enzymes pour optimiser leurs activités catalytiques dans des conditions environnementales particulières. Selon certains modes de mise en oeuvre préférés, la présente invention concerne des procédés visant à modifier la charge superficielle nette et/ou la distribution de charge superficielle des enzymes (telles que des métalloprotéases ou des sérines protéases) pour obtenir des variantes d'enzymes qui présentent une meilleure performance dans des formulations détergentes comparé à l'enzyme de départ ou enzyme parent.

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