C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2148599
The present invention relates to a stably co-transfected eukaryotic cell line capable of expressing an N-methyl-D-aspartate (NMDA) receptor, particularly a human NMDA receptor, which receptor comprises at least one R1 subunit isoform, or at least one R1 subunit isoform and one or two R2 subunits; to the cloning of novel cDNA sequences encoding the human NMDA R2A subunit and various isoforms of the human NMDA R1 subunit; and to the use of the cell line in designing and developing NMDA receptor subtype-selective medicaments.
Le Bourdelles Beatrice
Myers Janice Ann
Whiting Paul John
Gowling Lafleur Henderson Llp
Merck Sharp & Dohme Limited
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