Mercaptopurine derivatives as anticancer agents

Details Mercaptopurine derivatives as anticancer agents Mercaptopurine derivatives as anticancer agents

C - Chemistry, Metallurgy

07

D

C07D 473/38 (2006.01) A61K 31/52 (2006.01) A61K 31/708 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07H 19/167 (2006.01)

Patent

CA 2679700

The invention provides novel mercaptopurine derivatives of formula x-s-s-y, e.g., S-allylthio-6-mercaptopurine and S -allylthio- 6 -mercaptopurine 9 -riboside, as well as pharmaceutical compositions thereof. These compounds are highly efficient anti -proliferative agents, thus can be useful for treatment of various diseases or disorders, in particular, proliferative, inflammatory, skin and immune diseases or disorders.

L'invention concerne des dérivés de mercaptopurine atypiques représentés par la formule x-s-s-y, par exemple S-allylthio-6-mercaptopurine et S -allylthio- 6 -mercaptopurine 9 -riboside, ainsi que des compositions pharmaceutiques de ceux-ci. Ces composés sont des agents antiprolifératifs très efficaces, et peuvent par conséquent être utiles pour le traitement de divers troubles et maladies, en particulier des maladies ou des troubles prolifératifs, inflammatoires, cutanés et du système immunitaire.

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