Purification of immunoglobulins

Details Purification of immunoglobulins Purification of immunoglobulins

B - Operations, Transporting

01

D

B01D 15/32 (2006.01) B01D 15/38 (2006.01) B01J 20/281 (2006.01) B01J 39/26 (2006.01) C07K 1/22 (2006.01) B01D 15/18 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2586803

The present invention relates to a separation matrix comprised of porous particles to which antibody-binding protein ligands have been immobilised, wherein the ligand density is in the range of 5.0-10 mg/ml; the gel phase distribution coefficient of the particles expressed as Kav for a dextran of size 110 kDa is above 0.65 and the median particle di-ameter is between 65 - 84 ~m. The carbohydrate material is preferably highly cross-linked agarose.

L'invention concerne une matrice de séparation comprenant des particules poreuses sur lesquelles ont été immobilisées des ligands de protéine de liaison aux anticorps, sachant que la densité de ligand se situe dans la gamme 5-10 mg/ml ; le coefficient de distribution de phase de gel des particules exprimé par Kav pour un dextrane ayant une taille de 110 kDa est supérieur à 0,65, et le diamètre de particule moyen se situe dans la gamme 65 - 84 ?m. De préférence, le matériau en hydrate de carbone est de l'agarose hautement réticulé.

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