Spiro-piperidine derivatives as via receptor antagonists

Details Spiro-piperidine derivatives as via receptor antagonists Spiro-piperidine derivatives as via receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61P 9/00 (2006.01) C07D 491/10 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2670674

The present invention is concerned with novel indol-2-yl-carbonyl-spiro-piperidine derivatives as VIa receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. The compounds of present invention are represented by the general formula (I) wherein R1 to R1, X and Y are as defined in the specification.

Cette invention concerne des dérivés d'indol-2-yl-carbonyl-pipéridine en tant qu'antagonistes du récepteur V1a, leur fabrication, des compositions pharmaceutiques les renfermant et leurs utilisations en tant que médicaments. Les composés actifs de l'invention conviennent pour la prévention et/ou le traitement de l'angoisse et des troubles à caractère dépressif et autres pathologies. Les composés de cette invention sont représentés par la formule générale (I) dans laquelle R1 à R1, X et Y sont comme définis dans le descriptif.

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