Stabilization of isothiazolone

A - Human Necessities – 01 – N

Patent

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Details

A01N 43/80 (2006.01) A01N 25/22 (2006.01) A01N 43/56 (2006.01) A01N 47/34 (2006.01) A61K 31/425 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2372812

The present invention provides a highly stable formulation having broad spectrum preservative properties. The formulation is an admixture of dialkanol- substituted dimethyhydantoin, one or more isothiazolone compounds, a hydantoin stabilizer, and a hydroxyl solvent. The formulation is highly stable in pH ranges of about 4 to 8. Preferably the active components are dimethyloldimethylhydantoin, chloromethyllisothiazolone and methylisothiazolone, and the stabilizer dimethylhydantoin. The formulation has a free formaldehyde content of less than 0.2 % and is beneficial for preserving various aqueous compositions, including household and industrial products, and especially personal care products, which require a less acidic pH range than in which isothiazolone is stable in the presence of cationic salts.

L'invention concerne une formulation très stable ayant des propriétés de préservation à large spectre, qui est un mélange des éléments suivants: diméthylhydantoïne à substitution dialkanol, un ou plusieurs composés isothiazolone, un stabilisant hydantoïne, et un solvant hydroxyle. La formulation est très stable dans des gammes de pH comprises environ entre 4 et 8. De préférence, les composants actifs sont les suivants: diméthyloldiméthylhydantoïne, chlorométhylisothiazolone et méthylisothiazolone; et le stabilisant est diméthylhydantoïne. La formulation a une teneur en formaldéhyde libre inférieure à 0,2 % et elle est utile pour la préservation de diverses compositions aqueuses, y compris les produits ménagers et industriels, et en particulier les produits de soins personnels, qui nécessitent une gamme de pH moins acide dans laquelle l'isothiazolone est stable en présence de sels cationiques.

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