C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/45 (2006.01) A61K 35/76 (2006.01) A61K 39/155 (2006.01) A61P 31/14 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12P 21/04 (2006.01)
Patent
CA 2467958
Recombinant human parainfluenza virus type I (HPIVI) composiitions, formulations, and methods are provided. The recombinant HPIVI viruses and HPIVI chimeric and chimeric vector viruses provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, are useful in immunogenic composition s for eliciting an immune responses against one or more PIVs, against one or more non-PIV pathogens, or against a PIV and a non-PIV pathogen. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant HPIVI genome or antigenome.
L'invention concerne des méthodes, des préparations et des compositions comprenant un virus parainfluenza de type 1 humain (HPIV1) recombinant. Les virus HPIV1 recombinants ainsi que les virus vecteurs chimériques et les virus chimériques HPIV1 décrits dans cette invention sont infectieux et atténués chez des sujets mammifères réceptifs, y compris chez l'homme, et sont utiles dans des compositions immunogènes destinées à induire des réponses immunitaires dirigées contre un ou plusieurs virus PIV, contre un ou plusieurs agents pathogènes non PIV, ou contre un virus PIV et un agent pathogène non PIV. L'invention concerne également des molécules polynucléotidiques isolées et des vecteurs comprenant un génome ou un antigénome du HPIV1 recombinant.
Collins Peter L.
Murphy Brian R.
Newman Jason T.
Skiadopoulos Mario H.
Fetherstonhaugh & Co.
The Government Of The United States Of America As Represented By
LandOfFree
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